TOP 6 MOST TOXIC ANIMALS IN THE WORLD These animals may look small or harmless, but their toxins can be deadly. Some use poison to defend themselves, while others use venom to hunt. Here are six of the most toxic creatures on Earth and how they can affect humans. 1. GOLDEN POISON DART FROG Found in Colombia, this tiny, colorful frog carries enough poison in its skin to kill 10 grown humans. Just touching it can be dangerous. Indigenous people once used its toxins on blow darts for hunting. 2. IN