transcription factor for T helper type I (Th1) immunity, which is fundamental for the immune response to intracellular pathogens but also underlies in ammatory diseases.
Th1 cells drive the type-1 pathway (“cellular immunity”) to fight viruses and other intracellular pathogens, eliminate cancerous cells, and stimulate delayed-type hypersensitivity (DTH) skin …
The Th1 cell family including Th1 cells, transcription factor T-bet, and related cytokines IFNg, TNFa, IL-2, IL-18, TGF-b, and IL-12 have been widely discussed in autoimmunity, such as SLE.
TH1 dominance (IFN-γ ↑, IL-4 ↓) is usually a consequence of an increased but otherwise intact immune response, e.g., during an ongoing infection but also as a result of therapeu-tic …
BENEFITS Supports healthy activation of Th1 cells to promote innate immunity and cell-mediated immune defenses‡ Helps maintain healthy immune biomarkers related to cell tissue health …
Feb 6, 2025 · In order to establish Ser499Ala 449 and Thr510Ala mutations before the onset of Th1 cell differentiation, Th1 cell 450 differentiation was induced already on the 3rd day after …
Initially, two major types of CD4+ T helper (Th) effector cells were identified, and named as type 1 (Th1) and type 2 (Th2) cells because of the different cytokines they produce. More recently, a …