transcription factor for T helper type I (Th1) immunity, which is fundamental for the immune response to intracellular pathogens but also underlies in ammatory diseases.

Th1 cells drive the type-1 pathway (“cellular immunity”) to fight viruses and other intracellular pathogens, eliminate cancerous cells, and stimulate delayed-type hypersensitivity (DTH) skin reactions.

The Th1 cell family including Th1 cells, transcription factor T-bet, and related cytokines IFNg, TNFa, IL-2, IL-18, TGF-b, and IL-12 have been widely discussed in autoimmunity, such as SLE.

TH1 dominance (IFN-γ ↑, IL-4 ↓) is usually a consequence of an increased but otherwise intact immune response, e.g., during an ongoing infection but also as a result of therapeu-tic immunostimulation.

BENEFITS Supports healthy activation of Th1 cells to promote innate immunity and cell-mediated immune defenses‡ Helps maintain healthy immune biomarkers related to cell tissue health and …

Feb 6, 2025 · In order to establish Ser499Ala 449 and Thr510Ala mutations before the onset of Th1 cell differentiation, Th1 cell 450 differentiation was induced already on the 3rd day after CRISPR editing.

Initially, two major types of CD4+ T helper (Th) effector cells were identified, and named as type 1 (Th1) and type 2 (Th2) cells because of the different cytokines they produce. More recently, a third type of …