Protease mechanisms Protease mechanisms Polypeptides can be cleaved either chemically or enzymatically. Enzymes that catalyse the hydrolytic cleavage of peptide bonds are called proteases.

Dec 18, 2025 · Proteases articles from across Nature Portfolio Atom RSS Feed Proteases are enzymes that catalyse hydrolysis of the peptide and isopeptide bonds that join amino acids within proteins …

Aug 24, 2010 · The first serine protease scientists explored in detail was chymotrypsin, a digestive enzyme synthesized in our pancreas, along with the related enzymes trypsin and elastase.

Oct 29, 2024 · Protease enzymes, in particular, have proven to be cost-effective, stable, and compatible alternatives to traditional chemical processes in both industrial and environmental applications.

Jul 1, 2025 · Substrate-specific proteases have an enormous potential in the life sciences, but tailoring their specificity remains challenging. Here, the authors describe a data-driven approach combining …

Feb 25, 2025 · The bacterial Lon protease was recently identified as a potent inhibitor of human MYC, with effects on MYC-dependent gene expression and therapeutic efficacy in models of bladder and …

The status of human protease research and prospects for future protease-targeted drugs are reviewed here, with reference to some key examples where protease drugs have succeeded or failed.

Apr 22, 2025 · Structural and biochemical studies of the monkeypox virus core protease show that it exists as an active homodimer and indicate that the substrate-binding sites of core proteases are a …

Feb 19, 2025 · Lon protease 1 (LONP1) is an ATP-dependent protease located in the mitochondrial matrix and plays a crucial role in regulating mitochondrial proteostasis, metabolism, and cellular …

Jan 15, 2025 · Engineering of a human-derived protease controlled exogenously by its FDA-approved inhibitor enables control over cytokine activity in cell-based therapies with reduced risk of …