UCSF order sets and ERAS pathways promote the use of multimodal analgesia to improve pain control and to minimize opioid use.

Multiple classes of systemic analgesic medications have been used to accomplish these tasks, and the aim of this article is to outline these medications, their mechanisms of action, as well …

This article is not intended to deter clinicians from using opioids as an analgesic altogether, especially after surgery; instead, it offers strategies to mitigate the opioid-related side effects, …

Sep 11, 2024 · The current paradigm of perioperative pain management is called multimodal analgesia. Treatment for surgical pain begins preoperatively, is managed intraoperatively by …

Multi-modal analgesia is defined as the use of different classes of analgesic drugs that act at various sites in the pain pathway to achieve effective pain relief, often allowing for reduced …

Dec 19, 2025 · We hypothesize that multimodal analgesia will demonstrate superior outcomes compared to traditional opioid-centric approaches, with variations influenced by surgical type, …

Aug 6, 2025 · By targeting different pain mechanisms simultaneously, multimodal strategies can provide superior analgesia compared to single-modality approaches, while potentially reducing …

Jun 21, 2018 · Multimodal analgesia refers to the practice of combining different types of medications for pain management. Using multimodal analgesia techniques to manage short …

Multimodal analgesia is the administration of a combination of analgesics with different modes or sites of action. It is a strategy that reduces opioids use and prescriptions through the use of …

By selecting pharmacological agents that act on different channels, enzymes, and receptors, surgeons can leverage the additive and synergistic mechanisms of analgesia provided by …