Computational models of the glucoregulatory system constitute a powerful tool for preclinical evaluation and mechanistic insight into therapeutics. However, in the case of diabetes, there is a dearth ...

Vascular stenosis is the narrowing of blood vessels due to plaque buildup within the vessel walls. It disturbs the blood flow dynamics in microvessels, leading to platelet activation and aggregation ...

Keratinases is a special hydrolytic enzyme produced by microorganisms, which has the ability to catalyze the degradation of keratin. Currently, keratinases show great potential for application in many ...

Hybrid small-molecule/protein fluorescent probes are powerful tools for visualizing protein localization and function in living cells. These hybrid probes are constructed by diverse site-specific ...

The regulation of the immune microenvironment is a key component of wound healing, where suitable wound dressings with skin immunoreactivity can favorably affect the immune process and promote the ...

Bioelectronic devices are designed to translate biological information into electrical signals and vice versa, thereby bridging the gap between the living biological world and electronic systems.

Here, we report a photo- and copper-catalyzed enantioselective oxidation of benzylic C(sp3)–H bonds using N-hydroxyphthalimide as the oxygenated reagent. The reaction proceeds under mild conditions ...

Alcohols and aryl carboxylic acids are among the most commercially abundant, synthetically versatile, and operationally convenient building blocks in organic chemistry. Despite their widespread ...

mRNA therapy holds significant promise for preventing and treating diverse diseases. The development of safe and effective cationic polymers for mRNA delivery is essential for advancing its clinical ...

Chiral 1-tetrahydronaphthamides are the core structures of many bioactive molecules, yet their efficient asymmetric synthesis from a simple feedstock remains a challenge. Herein, we present a one-pot ...

A wide variety of reactions are reported to be dramatically accelerated in aqueous microdroplets, making them a promising platform for environmentally clean chemical synthesis. However, to fully ...

The production of many bulk chemicals relies on heterogeneous catalysis. The rational design or improvement of the required catalysts critically depends on insights into the underlying mechanisms on ...