BK and CaV1.3 channels interact early during biogenesis, assembling intracellularly before membrane localization, indicating ...

Trained immunity provides a unifying framework linking innate immune memory to both protective and maladaptive inflammation ...

This important study, which tackles the challenge of analyzing genome integrity and instability in unicellular pathogens by introducing a novel single-cell genomics approach, presents compelling ...

An agreement between universities, research institutes and funders to support the career development of researchers in the UK has led to improvements in research culture since 2019, but there is still ...

A context-driven memory model simulates a wide range of characteristics of waking and sleeping hippocampal replay, providing ...

A new CRISPR-based approach for tuning gene expression up and down allowed identification of how other genes' expression responds to changes of transcription factors.

CDK2-mediated TBK1 degradation via Dtx4 represents a previously unrecognized regulatory mechanism that modulates antiviral immunity in fish.

Lipid imbalance triggered by Snail-driven epithelial–mesenchymal transition creates a cholesterol-dependent vulnerability ...

A large-scale investigation of carnivoran brain diversity, providing a unified description of folding patterns, their relationship to behaviour and ecology, and the foundation for future ...

In silico antibody accessibility analysis indicates that ectodomain epitopes are transiently exposed, while MPER epitopes are virtually always occluded in the pre-fusion trimer.

The orbitofrontal cortex (OFC) is critical to identifying task structure and to generalizing appropriately across task states with similar underlying or hidden causes. This capability is at the heart ...

Non-coding DNA is essential for both humans and trypanosomes, despite the large evolutionary divergence between these two species.