Following Real Madrid's opening day clash against Osasuna, Alonso's men will face off with Real Oviedo and Mallorca to close out August. Just over a month into the 2025–26 campaign, Los Blancos will clash with Atlético Madrid at the Metropolitano. Real Madrid will host the second Madrid derby in March.

La Liga's fixture list for the upcoming season confirms Barcelona will play their first three matches of the league season away from home.

The duel between Real Madrid and Barcelona will return with two high-tension clashes: the first leg will be played at the Santiago Bernabéu, on the 10th matchday (October 26), while the return is scheduled for the 35th matchday, on May 10, at the renovated Spotify Camp Nou.