NFL preseason Week 2 often has significant consequences for position battles in fantasy football. Read how 2025's action from the second exhibition weekend should play into your fantasy drafts.

Week 2 of the 2025 NFL preseason slate sounded an alarm across the fantasy football community. Or it should have, anyway. Opening kick of the actual campaign is less than two weeks away. If fantasy football preparations aren't finalized yet, managers should at least be putting the final touches on those plans.

I changed the order of this group from Tiers 3.0. Since the last edition, Cook signed an extension with the Bills, and Walker continues to deal with a nagging foot injury. The rookie running backs have also continued to thrive, and I would draft Cook, Hampton and Henderson in Round 3, with Harvey and Walker in Round 4.

It is time to start preparing for your fantasy football season. Which quarterbacks should you target for your 2025 fantasy football drafts?

In your fantasy football draft, you can go from Zero to Hero very easily. Here are the running backs you can count on to lead you to paydirt.

SportsLine simulated the new NFL season 10,000 times and revealed its 2025 Fantasy football QB, RB, WR, TE, kicker and defense rankings