This review examines the cellular functions of the DNA topoisomerases from a mechanistic point of view. The following points are summarized. Classification of DNA topoisomerases into four subfamilies ...

Shortly after this Review was completed, we were saddened to learn that Dr Tao-shih Hsieh, of Duke University, Durham, North Carolina, USA, and Academia Sinica, Taipei, passed away. Hsieh was a true ...

Cambridge, MA, November 15, 2012 – A group of researchers at the University of California, Berkeley have for the first time described the structure of the active site core of topoisomerase II alpha, ...

Vaccinia virus encodes a type I DNA topoisomerase that is highly conserved in all known poxviruses. Although the structure and catalytic activity of the enzyme were well studied, little was known ...

Medical researchers have for the first time described the structure of the active site core of topoisomerase II alpha, an important target for anti-cancer drugs. The type II topoisomerases are ...