Videos are auto-populated by an affiliate. This site has no control over the videos that appear above. The San Francisco ...

Running back Isaac Guerendo is fast. And he's big. But the San Francisco 49ers rookie is a work in progress. His lone carry ...

The Rams are missing five starters on offense and the 49ers are missing three, which means there might not be much scoring in ...

When the schedule came out in May, this Week 3 matchup between the 49ers and the Rams looked like it would be a great game ...

San Francisco 49ers safety Talanoa Hufanga is poised to make his season debut on Sunday against the Los Angeles Rams.

The 49ers have listed George Kittle as doubtful to play this Sunday against the Los Angeles Rams. That means backup tight end ...

According to data from Vivid Seats, 62 percent of the crowd at SoFi Stadium on Sunday is expected to support the visiting San ...

Los Angeles Rams offensive coordinator Mike LaFleur mentioned that having quarterback Jimmy Garoppolo in the locker room ...

Head coach Kyle Shanahan detailed the 49ers latest injury updates headed into the team's first NFC West matchup vs. the Los ...

The banged-up 49ers added three more names to the list of banged-up 49ers this week.Suddenly in doubt for the Week 3 game at ...

Check out some of S Talanoa Hufanga's must-visit spots around Los Angeles, California ahead of the 49ers vs. Rams Week ...

The Minnesota Vikings will be without wide receiver Jordan Addison on Sunday when they host the San Francisco 49ers at U.S.