The Los Angeles Rams are playing their NFC rivals at a favorable time. The San Francisco 49ers are short their two best offensive players in Christian McCaffrey and Deebo Samuel.

After spending six seasons in red and gold, the former 49ers quarterback will be on the opposing sideline on Sunday in Los Angeles.

Yet another San Francisco 49ers star seems set to miss Sunday’s matchup with the Los Angeles Rams. Tight end George Kittle is “likely” to miss Sunday’s game, ESPN insider Adam Schefter said on X on Thursday morning.

The last time the Los Angeles Rams and San Francisco 49ers met, head coaches Sean McVay and Kyle Shanahan were without some starters. That was Week 18 of the 2023 season, and both teams had already clinched playoff berths.

The Los Angeles Rams are currently facing a tough situation as they prepare for their Week 3 matchup against the San Francisco 49ers . An injury crisis is unfolding that could have serious consequences for their performance this season.