Glutamate transporters are integral membrane proteins that play critical roles in regulating excitatory neurotransmission by rapidly clearing glutamate from the synaptic cleft. They operate through a ...

Nucleobase transporters are essential membrane proteins that facilitate the selective uptake of purines and pyrimidines, fundamental building blocks for nucleic acid synthesis and cellular metabolism.

Chia-Hsueh Lee, PhD, and Yaxin Dai, PhD, St. Jude Department of Structural Biology obtained ten structures of the human urate transporter URAT1 to uncover the transporter’s mechanism of action and ...

The metabolic process of bilirubin has been a focus in medical research since the abnormal accumulation of bilirubin has been found to be associated with a variety of diseases. Bilirubin is a ...

A research team led by Prof. GUO Yusong, Associate Professor of the Division of Life Science at The Hong Kong University of ...

Special proteins -- known as membrane transporters -- are key to the mobility of sperm cells. A research team has, with the aid of cryo-electron microscopy, succeeded in decoding the structure of such ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 118, No. 32 (August 10, 2021), pp. 1-10 (10 pages) Lysosomes degrade excess or damaged cellular components and ...

Scientists have determined structures of a transporter protein involved in the movement of neurochemicals such as serotonin and dopamine, unearthing multiple mechanisms that can guide drug development ...

Pi plays crucial metabolic and structural roles in living organisms. It is essential for bioenergetics (ATP, GTP), metabolic regulation through glycolysis and oxidative phosphorylation, intercellular ...

University of Michigan researchers have discovered that the same cellular mechanism involved in a form of cystic fibrosis is also implicated in a form of a rare disease called cystinosis. The ...