A previous trial involving patients with metastatic prostate cancer that was resistant to androgen pathway modulation (formerly referred to as castration-resistant) showed that adding talazoparib ...

An AI-assisted drug discovery platform using transfer learning has identified a promising gp130 inhibitor for colorectal ...

A new review brings attention to the STING pathway as a critical regulator in both colitis and colon cancer, highlighting its complex and often opposing roles in inflammation and tumor development.

Recently, the research group led by Dr. Dechao Feng, Lecturer at University College London (UCL) and Distinguished Research ...

A comparative study of dosage strategies in HIPEC: BSA-based vs fixed dose methods.

The central image depicts currently used strategies for clinical targeting of TGF-β. Below are methods applicable from preclinical screening to clinical practice, including using humanized mouse ...

A team at Huntsman Cancer Institute at the University of Utah (the U) has uncovered a previously unrecognized molecular mechanism by which cells send signals to one another-insight that could help ...

For most children diagnosed with medulloblastoma, the most common malignant pediatric brain tumor, survival rates are encouraging. But for a subset, remission is not the end of the story. Roughly 30% ...

A new study found that resistant prostate tumors can switch from male hormone signaling to cortisol pathways. The findings ...

Oncologists have discovered that lung cancer cells can change their identity to resist treatment. Research published in ...