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Functionally redundant Rho GTPases Cdc42 and RacA regulate aflatoxin synthesis and pathogenicity in Aspergillus flavus by controlling morphogenesis, oxidative balance and ...

Rho GTPases Cdc42 and RacA share significant sequence homology and are conserved among eukaryotic species. These proteins act as molecular switches in various signal transduction pathways by cycling ...
Nature

Rho GTPase Signaling in Mechanotransduction

Mechanotransduction describes the process by which cells convert mechanical stimuli from their environment into biochemical signals. Central to this process are the Rho family of small GTPases, ...
Nature

Regulation of Rho GTPases in Cellular Dynamics

Rho GTPases constitute a pivotal family of small signalling proteins that act as molecular switches to orchestrate cytoskeletal dynamics, cell polarity, motility and membrane trafficking. Cycling ...
ascopubs.org

Frequent mutations of genes predisposing to Rho GTPase signal activation and autophagy inhibition in metastatic soft tissue sarcoma unveiled by paired somatic and germline ...

Results of the dose-finding phase of ARST 1321 from the Children's Oncology Group and NRG Oncology: Neoadjuvant chemoradiation or radiation therapy +/- pazopanib in non-rhabdomyosarcoma soft tissue ...
GEN

Chemical Genetics Shows How “Undruggable” GTPases Can Be Targeted

Scientists at the University of California, San Francisco (UCSF), have discovered how to target a class of molecular switches called GTPases that are involved in a myriad of diseases—from Parkinson’s ...