An engineered viral protein enhanced the anticancer function of T cells in mice, suggesting a new strategy to improve immunotherapy. Courtney and his team sought to exploit this property of TIP to ...

Persistent viral infections pose a unique challenge to the immune system. Prolonged antigen exposure drives T cells into a state of exhaustion — a ...

UCLA researchers gave T cells a protected supply of sugar, allowing them to attack solid tumors more effectively.

Diets and healthy eating habits hold promise for preventing and treating diseases, but far less is known about acute effects to the immune system shortly after a meal. In a study published today in ...

A team led by LMU physician Sebastian Kobold has found a way to allow the body's immune system to destroy solid tumors. In 2024, Professor Sebastian Kobold's research group at LMU University Hospital ...

The Notch signaling pathway plays a pivotal role in determining cell fate, especially in the development and function of T cells. But mimicking this highly mechanical, contact-dependent pathway in the ...

A study led by researchers at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) has identified a mitochondrial ...

The study, “Integration of phospho-signaling and transcriptomics in single cells reveals distinct Th17 cell fates,” was published in Cell Reports. In the study, first author Seth Fortmann, M.D., Ph.D.