Drugs are metabolized in the liver using several enzyme-catalyzed processes. These enzymes are collectively referred to as the hepatic microsomal enzyme system, and they are usually present in the ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, No. 6 (Mar. 15, 1992), pp. 2394-2398 (5 pages) Dietary composition is a major determinant of cancer risk in ...

Induction of cytochrome P450 (CYP) by drugs is one of major concerns for drug-drug interactions. Thus, the assessment of CYP induction by novel compounds is a vital component in the drug discovery and ...

Previous studies 6 have shown that the CC 50 (cytotoxic concentration of the compound that reduces cell viability by 50%, which indicates the cytotoxicity of a drug) value of triptolide was 2.1 nmol/L ...