Meanwhile, the 49ers are set to get some much-needed reinforcements on run defense, and Ricky Pearsall's status for Week 16 is unclear.

Tennessee Titans star Jeffery Simmons' Nashville home was burglarized by "at least six suspects" while he played against the 49ers, sparking an angry response.

San Francisco 49ers coach Kyle Shanahan has shared some concerning news following the team's win over the Tennessee Titans.

The San Francisco 49ers could be getting some unexpected speed injected into their receiving corps late in the 2025 season.

Two defensive stars were lost for the season. Their QB missed multiple games. Still, here are the 49ers are, a game out of the No. 1 seed.

Watkins is a very intriguing player, one who offers speed, route-running prowess and reliability at the catch point. Yet, unless the 49ers’ Week 18 game with the Seattle Seahawks proves a meaningless one in which both teams can rest starters, it looks as if he will have to wait until next season for significant action.

NFL Week 16 odds, picks, predictions, TV channel, streaming information for Monday Night Football between San Francisco 49ers and Indianapolis Colts.

Indianapolis Colts' head coach Shane Steichen confirmed on Monday that Phillip Rivers will start in next week's game against the San Francisco 49ers on Monday Night football. This announcement by Steichen doesn't come as a surprise. In Rivers' return to action against Seattle, he provided needed stability at the quarterback position.

Despite losing to the Seattle Seahawks on Sunday in his first start since the 2020 season, Indianapolis Colts veteran quarterback Philip Rivers will get his chance at redemption.